Trimethylglycine, also referred to as TMG or Betaine Anhydrous, is a naturally found compound crucial for the methylation cycle, essential for regulating numerous bodily functions.

Certain individuals possess variations in the MTHFR gene, affecting the methylation process. Research indicates that as many as half of the population may carry these gene variations, potentially hindering efficient methylation. Consequently, these individuals might not effectively utilize B-vitamins.